Vascular damage in chronic kidney disease and hypertension

Medicine 4

Head of Department:
Prof. Dr. med. Mario Schiffer
Team AG Hilgers (f.l.t.r.): Julian Panesar, Andrea Hartner, Karl Hilgers, Özge Kaya, Nada Cordasic, Rainer Wachtveitl, Miroslawa Kupraszewicz-Hutzler, Astrid Ziegler

Our group uses experimental models to investigate mechanisms of vascular damage in chronic kidney disease and hypertension. One focus of our work is on the syndrome of “malignant hypertension” which is characterized by rapidly progressive target organ injury despite blood pressure levels which are very similar to those observed in non-malignant hypertension. Current projects address the role of defective angiogenic pathways in this syndrome. The second focus of our group is the impaired angiogenic response to ischemia in chronic kidney disease. Patients with chronic kidney disease suffer disproportionally from cardiovascular disease; stenosis or occlusions of arterial vessels occur more often, and the sequelae of these macrovascular events tend to be more severe than in patients with normal kidney function. We have previously shown that the angiogenic processes induced by ischemia (which are required to restore tissue perfusion) are impaired in an experimental model of chronic kidney disease (see figure). Current projects focus on therapeutic interventions to improve ischemia-induced angiogenesis in chronic kidney disease.

Representative photomicrographs of preglomerular arterioles in malignant versus non-malignant hypertension following renal artery clipping. PAS stained renal sections of the contralateral (non-clipped!) kidney exposed to high blood pressure. Arrows mark arterioles. Panel A, renal section from a normotensive control; B, renal section non-malignant hypertension (only thickening of the media is visible but no other pathology). C and D, renal sections from malignant hypertension with arterioles showing fibrinoid necroses (panel C) or highly proliferative “onion-skin” lesion (panel D).
 
Group leader
Prof. Dr. med. Karl F. Hilgers
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Scientists
Dr. rer. biol. hum. Nada Cordasic
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Graduate students

Thomas Dambietz

Technicians

Rainer Wachtveitl
Miroslava Kupraszewicz-Hutzler

Collaborations