Transplantationszentrum
Prof. Dr. med. Johannes Schödel D. phil.
Oberarzt, Facharzt für Innere Medizin, Facharzt für Innere Medizin und Nephrologie, Zusatzbezeichnungen für Internistische Intensivmedizin und Transplantationsmedizin
Ulmenweg 18
91054 Erlangen
Building
Internistisches Zentrum (INZ)
Institutions
Medizin 4
Transplantationszentrum
Education, Training and Academic Positions
Publications
- (2022) The renal cancer risk allele at 14q24.2 activates a novel hypoxia-inducible transcription factor-binding enhancer of DPF3 expression. J Biol Chem. 2022;298(3):
- (2022) Loss of Polycystin-1 causes cAMP-dependent switch from tubule to cyst formation. iScience. 2022;25(6):
- (2021) Androglobin gene expression patterns and FOXJ1-dependent regulation indicate its functional association with ciliogenesis. J Biol Chem. 2021;296():
- (2021) Significance of Glomerular Immune Reactivity in Time Zero Biopsies for Allograft Survival Beyond IgA. Front Med (Lausanne). 2021;8():
- (2020) Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI. J Biol Chem. 2020;295(13): 4065-4078
- (2020) Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression. Haematologica. 2020;105(12): 2774-2784
- (2020) Molecular diagnosis of kidney transplant failure based on urine. Am J Transplant. 2020;20(5): 1410-1416
- (2020) Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner. J Mol Med. 2020;98(11): 1547-1559
- (2019) Now a Nobel gas: oxygen. Pflugers Arch. 2019;471(11-12): 1343-1358
- (2019) Mechanisms of hypoxia signalling: new implications for nephrology. Nat Rev Nephrol. 2019;15(10): 641-659
- (2019) Hypercalcemia mimicking myocardial infarction. Kidney Int. 2019;96(6): 1428-1428
- (2017) Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway. PLoS Genet. 2017;13(7): e1006872
- (2017) Posttranscriptional Regulation of LOXL1 Expression Via Alternative Splicing and Nonsense-Mediated mRNA Decay as an Adaptive Stress Response. Invest Ophthalmol Vis Sci. 2017;58(13): 5930-5940
- (2017) Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1. Nat Commun. 2017;8(): 15466
- (2016) Hypoxia-inducible Factor Crosses the Checkpoint. Eur Urol. 2016;70(4): 633-634
- (2016) P2Y2R is a direct target of HIF-1? and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells. Purinergic Signal. 2016;12(4): 687-695
- (2016) Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer Nat Commun. 2016;7(): 13183-
- (2015) Hypoxia and hypoxia-inducible factors in myeloid cell-driven host defense and tissue homeostasis. Immunobiology. 2015;220(2): 305-314
- (2015) Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1? upon LPS Activation in the Presence of Ample Oxygen. Cell Rep. 2015;13(10): 2048-55
- (2015) Destruction of a distal hypoxia response element abolishes trans-activation of the PAG1 gene mediated by HIF-independent chromatin looping. Nucleic Acids Res. 2015;43(12): 5810-23
- (2015) Tumor hypoxia induces nuclear paraspeckle formation through HIF-2? dependent transcriptional activation of NEAT1 leading to cancer cell survival. Oncogene. 2015;34(34): 4482-90
- (2014) Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2. EMBO Rep. 2014;15(1): 70-6
- (2014) Optimal translational termination requires C4 lysyl hydroxylation of eRF1. Mol Cell. 2014;53(4): 645-54
- (2014) ANALYSES OF HYPOXIA INDUCIBLE TRANSCRIPTION FACTOR DNA-BINDING AND HYPOXIC GENE REGULATION IN PRIMARY HUMAN RENAL TUBULAR CELLS Nephrol Dial Transplant. 2014;29 3(): 330-330
- (2012) Selective stabilization of HIF-1? in renal tubular cells by 2-oxoglutarate analogues. Am J Pathol. 2012;181(5): 1595-606
- (2012) Renal Tubular HIF-2? Expression Requires VHL Inactivation and Causes Fibrosis and Cysts. PLoS ONE. 2012;7(1): e31034
- (2011) Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1? (HIF1A) and result in differential HIF1A-dependent gene expression. J Leukoc Biol. 2011;90(3): 551-62
- (2011) Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury. J Am Soc Nephrol. 2011;22(11): 2004-15
- (2010) The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1. J Biol Chem. 2010;285(9): 6658-69
- (2010) Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. FASEB J. 2010;24(11): 4443-58
- (2010) Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells. Kidney Int. 2010;78(9): 857-67
- (2009) HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia. Cell Cycle. 2009;8(9): 1386-95
- (2009) HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Am J Pathol. 2009;174(5): 1663-74
- (2009) Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model. Proc Natl Acad Sci U S A. 2009;106(50): 21276-81
Consultations
Tumorerkrankungen (genetisch) der Niere
Special consultation hour
Prof. Dr. med. Johannes Schödel D. phil.
Zeiten
nach Vereinbarung
Internistisches Zentrum (INZ)
Ulmenweg 18
91054 Erlangen
Room
D 0 723-1
Contact for appointments
Appointments only upon consultation
Appointments only upon consultation
Hochschulambulanz
Montag bis Freitag
11.00 - 15.00 Uhr
Telefon: 09131 85-32566
Fax: 09131 85-33431
Hinweis
In enger Kooperation mit der Klinik für Urologie betreuen wir Patienten mit genetischen Tumorerkrankungen der Nieren (z. B. von-Hippel-Lindau-Syndrom) und seltenen Polyzythämie Syndromen.
Required documents
- Certificate of Insurance (health insurance card)
- Allocation
- Medication list
- Befundberichte von Ihrem Facharzt (falls vorhanden)
To all contacts
