Prof. Dr. med. Karl F. Hilgers
Stellvertretender Direktor, Facharzt für Innere Medizin, Hypertensiologe (DHL)
Ulmenweg 18
91054 Erlangen
Building
Internistisches Zentrum (INZ)
Institutions
Medizin 4
Transplantationszentrum
Education, Training and Academic Positions
Publications
- (2022) Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling. Sci Rep. 2022;12(1):
- (2022) Empagliflozin Improves Impaired Sensitivity Of Afferent Neurons With Renal Axons Hypertension. 2022;79 Suppl 1():
- (2022) High Sodium Intake Effects On Afferent Renal Nerve Activity Hypertension. 2022;79 Suppl 1():
- (2022) Vitamin K1 and progression of cardiovascular calcifications in hemodialysis patients: the VitaVasK randomized controlled trial Clin Kidney J. 2022;15(12): 2300-2311
- (2021) Adaptive physiological water conservation explains hypertension and muscle catabolism in experimental chronic renal failure. Acta Physiol (Oxf). 2021;232(1):
- (2021) RNA sequencing reveals induction of specific renal inflammatory pathways in a rat model of malignant hypertension. J Mol Med. 2021;99(12): 1727-1740
- (2021) AT II Receptor Blockade and Renal Denervation: Different Interventions with Comparable Renal Effects? Kidney Blood Press Res. 2021;46(3): 331-341
- (2021) Responsiveness of afferent renal nerve units in renovascular hypertension in rats. Pflugers Arch. 2021;473(10): 1617-1629
- (2021) Neonatal nephron loss during active nephrogenesis results in altered expression of renal developmental genes and markers of kidney injury. Physiol Genomics. 2021;53(12): 509-517
- (2021) Neurogenic substance P-influences on action potential production in afferent neurons of the kidney? Pflugers Arch. 2021;473(4): 633-646
- (2020) Neurogenic tachykinin mechanisms in experimental nephritis of rats. Pflugers Arch. 2020;472(12): 1705-1717
- (2020) Afferent renal innervation in anti-Thy1.1 nephritis in rats. Am J Physiol Renal Physiol. 2020;319(5): F822-F832
- (2020) Correlations Between Interleukin-11 Expression and Hypertensive Kidney Injury in a Rat Model of Renovascular Hypertension. Am J Hypertens. 2020;33(4): 331-340
- (2020) A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney. Mol Cell Pediatr. 2020;7(1):
- (2020) After ten years of follow-up, no difference between supportive care plus immunosuppression and supportive care alone in IgA nephropathy. Kidney Int. 2020;98(4): 1044-1052
- (2019) Association of donor hypertension and recipient renal function in living donor kidney transplantation: A single-center retrospective study. Clin Transplant. 2019;33(10):
- (2019) Suspected colonic cancer turns out to be disseminated tuberculosis in a kidney transplant recipient: A case report. Medicine (Baltimore). 2019;98(36):
- (2019) Quantitative assessment of microperfusion by indocyanine green angiography in kidney transplantation resembles chronic morphological changes in kidney specimens. Microcirculation. 2019;26(3):
- (2019) Renal Chemerin Expression is Induced in Models of Hypertensive Nephropathy and Glomerulonephritis and Correlates with Markers of Inflammation and Fibrosis. Int J Mol Sci. 2019;20(24):
- (2019) Overexpression of Alanine-Glyoxylate Aminotransferase 2 in Mice Lowers Asymmetric Dimethylarginine and Improves Vasomotor Function Circulation. 2019;140 Suppl 1():
- (2018) In-situ analysis of mast cells and dendritic cells in coronary atherosclerosis in chronic kidney disease (CKD). Histol Histopathol. 2018;33(8): 871-886
- (2018) Neonatal nephron loss during active nephrogenesis - detrimental impact with long-term renal consequences. Sci Rep. 2018;8(1):
- (2018) Blood pressure control in chronic kidney disease: A cross-sectional analysis from the German Chronic Kidney Disease (GCKD) study. PLoS ONE. 2018;13(8): e0202604
- (2018) Correction: Blood pressure control in chronic kidney disease: A cross-sectional analysis from the German Chronic Kidney Disease (GCKD) study. PLoS ONE. 2018;13(9):
- (2018) Mild Salt-Sensitive Hypertension in Genetically Determined Low Nephron Number is Associated with Chloride but Not Sodium Retention. Kidney Blood Press Res. 2018;43(1): 1-11
- (2017) Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease. Kidney Int. 2017;91(3): 616-627
- (2017) Specific Aldosterone Synthase Inhibition: A Potential Improvement Over Mineralocorticoid Receptor Antagonism? Hypertension. 2017;69(1): 11-12
- (2017) ADHERE: randomized controlled trial comparing renal function in de novo kidney transplant recipients receiving prolonged-release tacrolimus plus mycophenolate mofetil or sirolimus. Transpl Int. 2017;30(1): 83-95
- (2017) Vascular inflammation and media calcification are already present in early stages of chronic kidney disease. Cardiovasc Pathol. 2017;27(): 57-67
- (2017) Blunted transcriptional response to skeletal muscle ischemia in rats with chronic kidney disease: potential role for impaired ischemia-induced angiogenesis. Physiol Genomics. 2017;49(4): 230-237
- (2017) Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8. Biol Sex Differ. 2017;8(): 19
- (2017) Dosing of indocyanine green for intraoperative laser fluorescence angiography in kidney transplantation. Microcirculation. 2017;24(8):
- (2017) [How to Retard Progression of Chronic Kidney Disease]. Dtsch Med Wochenschr. 2017;142(17): 1282-1289
- (2017) Genetic risk variants for membranous nephropathy: extension of and association with other chronic kidney disease aetiologies. Nephrol Dial Transplant. 2017;32(2): 325-332
- (2016) Deceased Donor Kidney Transplantation in the Eurotransplant Senior Program (ESP): A Single-Center Experience from 2008 to 2013. Ann Transplant. 2016;21(): 94-104
- (2016) Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover. PLoS ONE. 2016;11(3): e0150471
- (2016) Glycaemic control and antidiabetic therapy in patients with diabetes mellitus and chronic kidney disease - cross-sectional data from the German Chronic Kidney Disease (GCKD) cohort. BMC Nephrol. 2016;17(1): 59
- (2016) Impaired Neovascularization and Reduced Capillary Supply in the Malignant vs. Non-malignant Course of Experimental Renovascular Hypertension. Front Physiol. 2016;7(): 370
- (2015) Under-expression of ?8 integrin aggravates experimental atherosclerosis. J Pathol. 2015;236(1): 5-16
- (2015) High salt reduces the activation of IL-4- and IL-13-stimulated macrophages. J Clin Invest. 2015;125(11): 4223-38
- (2015) Intensive Supportive Care plus Immunosuppression in IgA Nephropathy. N Engl J Med. 2015;373(23): 2225-36
- (2014) Darbepoetin alpha reduces oxidative stress and chronic inflammation in atherosclerotic lesions of apo e deficient mice in experimental renal failure. PLoS ONE. 2014;9(2): e88601
- (2014) Contribution of the ?8 integrin chain to the expression of extracellular matrix components. Cell Commun Adhes. 2014;21(2): 89-98
- (2014) What should be the goal blood pressure in nondiabetic chronic kidney disease? Curr Opin Nephrol Hypertens. 2014;23(2): 180-5
- (2014) Effect of lowering asymmetric dimethylarginine (ADMA) on vascular pathology in atherosclerotic ApoE-deficient mice with reduced renal mass. Int J Mol Sci. 2014;15(4): 5522-35
- (2014) Impaired myocardial performance in a normotensive rat model of intrauterine growth restriction. Pediatr Res. 2014;75(6): 697-706
- (2014) Donor acute kidney injury and short-term graft outcome in renal transplantation. Clin Transplant. 2014;28(10): 1131-41
- (2014) Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells. Cell Adh Migr. 2014;8(4): 389-95
- (2014) Renal protection by low dose irbesartan in diabetic nephropathy is paralleled by a reduction of inflammation, not of endoplasmic reticulum stress Biochim Biophys Acta Mol Basis Dis. 2014;1842(4): 558-565
- (2013) Reduced Firing Activity of Afferent Renal Innervation in the 2kidney/1clip Model of Hypertension Hypertension. 2013;62 S(3): -
- (2013) Circulating dendritic cell precursors in chronic kidney disease: a cross-sectional study. BMC Nephrol. 2013;14(): 274
- (2013) Intrauterine growth restriction leads to a dysregulation of Wilms' tumour supressor gene 1 (WT1) and to early podocyte alterations. Nephrol Dial Transplant. 2013;28(6): 1407-17
- (2013) Hypertension: Resistant hypertension matters in chronic kidney disease. Nat Rev Nephrol. 2013;9(8): 441-2
- (2013) BK viremia and polyomavirus nephropathy in 352 kidney transplants; risk factors and potential role of mTOR inhibition. BMC Nephrol. 2013;14(): 207
- (2013) Cardiovascular and Renal Effects of High Salt Diet in GDNF+/- Mice with Low Nephron Number. Kidney Blood Press Res. 2013;37(4-5): 379-91
- (2012) Intrauterine growth restriction promotes vascular remodelling following carotid artery ligation in rats. Clin Sci (Lond). 2012;123(7): 437-44
- (2012) An experimental procedure paid for by the general public. Dtsch Arztebl Int. 2012;109(17): 311-2; author reply 313-4
- (2012) Tubulointerstitial de novo expression of the ?8 integrin chain in a rodent model of renal fibrosis - a potential target for anti-fibrotic therapy? PLoS ONE. 2012;7(11): e48362
- (2012) The German Chronic Kidney Disease (GCKD) study: design and methods. Nephrol Dial Transplant. 2012;27(4): 1454-60
- (2012) From red to white urine: a patient's nightmare with a rather benign outcome. BMC Nephrol. 2012;13(): 7
- (2012) A complex microdeletion 17q12 phenotype in a patient with recurrent de novo membranous nephropathy. BMC Nephrol. 2012;13(): 27
- (2011) Early glomerular alterations in genetically determined low nephron number. Am J Physiol Renal Physiol. 2011;300(2): F521-30
- (2011) Sympathetic blockade prevents the decrease in cardiac VEGF expression and capillary supply in experimental renal failure. Am J Physiol Renal Physiol. 2011;300(1): F105-12
- (2011) High-dose enalapril treatment reverses myocardial fibrosis in experimental uremic cardiomyopathy. PLoS ONE. 2011;6(1): e15287
- (2011) Association of (pro)renin receptor gene polymorphism with blood pressure in Caucasian men. Pharmacogenet Genomics. 2011;21(6): 347-9
- (2011) Early and late postnatal myocardial and vascular changes in a protein restriction rat model of intrauterine growth restriction. PLoS ONE. 2011;6(5): e20369
- (2011) Effect of the plasminogen-plasmin system on hypertensive renal and cardiac damage. J Hypertens. 2011;29(8): 1602-12
- (2010) An unusual case of hyponatraemia. Nephrol Dial Transplant. 2010;25(3): 998-1001
- (2010) Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine. Am J Pathol. 2010;176(5): 2559-70
- (2010) Severe metabolic alkalosis and recurrent acute on chronic kidney injury in a patient with Crohn's disease. BMC Nephrol. 2010;11(): 6
- (2010) Images in vascular medicine: Renal arteriovenous fistula. Vasc Med. 2010;15(5): 433-4
- (2010) Effects of adrenomedullin on the glomerular adrenomedullin system in a rat model of anti-thy1 glomerulonephritis. Nephron Exp Nephrol. 2010;115(3): e80-8
- (2010) Lack of {alpha}8-integrin aggravates podocyte injury in experimental diabetic nephropathy. Am J Physiol Renal Physiol. 2010;299(5): F1151-7
- (2010) Lack of ?8 integrin leads to morphological changes in renal mesangial cells, but not in vascular smooth muscle cells. BMC Cell Biol. 2010;11(): 102
- (2009) Deletion of the alpha8 integrin gene does not protect mice from myocardial fibrosis in DOCA hypertension. Am J Hypertens. 2009;22(1): 92-9
- (2009) Renal vascular endothelial function in hypertensive patients with type 2 diabetes mellitus. Am J Kidney Dis. 2009;53(2): 281-9
- (2009) Lack of nidogen-2 increases blood pressure, glomerular and tubulointerstitial damage in DOCA-salt hypertension. Eur J Clin Invest. 2009;39(2): 116-25
- (2009) Statin treatment reduces glomerular inflammation and podocyte damage in rat deoxycorticosterone-acetate-salt hypertension. J Hypertens. 2009;27(2): 376-85
- (2009) Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med. 2009;15(5): 545-52
- (2009) [In Process Citation] Urologe A. 2009;48(8): 925-33; quiz 934-5
- (2009) Developmental renin expression in mice with a defective renin-angiotensin system. Am J Physiol Renal Physiol. 2009;297(5): F1371-80
- (2009) C-reactive protein: more than just a marker of inflammation? J Hypertens. 2009;27(9): 1748-9
- (2009) New approaches to pathogenesis and management of hypertension. Clin J Am Soc Nephrol. 2009;4(12): 1886-91
- (2008) (Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in goldblatt rats. Hypertension. 2008;51(3): 676-81
- (2008) A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease. Nephron Clin Pract. 2008;108(3): c169-75
- (2008) [Chronic kidney disease and the cardiovascular system.] Internist (Berl). 2008;49(4): 413-21
- (2008) Acute syphilitic chorioretinitis after a missed primary diagnosis: a case report. J Med Case Reports. 2008;2(1): 33
- (2008) Autonomic renal denervation ameliorates experimental glomerulonephritis. J Am Soc Nephrol. 2008;19(7): 1371-8
- (2008) Blood pressure versus direct mineralocorticoid effects on kidney inflammation and fibrosis in DOCA-salt hypertension. Nephrol Dial Transplant. 2008;23(11): 3456-63
- (2008) Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a. Hypertension. 2008;52(1): 123-9
- (2008) Transient receptor potential vanilloid type 1 receptors in hypertensive renal damage: a promising therapeutic target? Hypertension. 2008;52(2): 213-4
- (2008) The choice of antihypertensive therapy in patients with the metabolic syndrome--time to change recommendations? Nephrol Dial Transplant. 2008;23(11): 3389-91
- (2008) [The kidneys and the heart] Dtsch Med Wochenschr. 2008;133(37): 1839-43
- (2008) Sodium-, potassium-, chloride-, and bicarbonate-related effects on blood pressure and electrolyte homeostasis in deoxycorticosterone acetate-treated rats. Am J Physiol Renal Physiol. 2008;295(6): F1752-63
- (2008) Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome. J Physiol. 2008;586(Pt 2): 459-75
- (2008) Rapid development of severe end-organ damage in C57BL/6 mice by combining DOCA salt and angiotensin II. Kidney Int. 2008;73(5): 643-50
- (2008) Glomerular regeneration is delayed in nephritic alpha 8-integrin-deficient mice: contribution of alpha 8-integrin to the regulation of mesangial cell apoptosis. Am J Nephrol. 2008;28(1): 168-78
- (2008) Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice. Am J Physiol Heart Circ Physiol. 2008;294(2): H1058-66
- (2007) Renal injury in streptozotocin-diabetic Ren2-transgenic rats is mainly dependent on hypertension, not on diabetes. Am J Physiol Renal Physiol. 2007;292(2): F820-7
- (2007) Mobilization of osmotically inactive Na+ by growth and by dietary salt restriction in rats. Am J Physiol Renal Physiol. 2007;292(5): F1490-500
Consultations
Elektrolytstörungen
Special consultation hour
PD Dr. med. Christoph Kopp
Prof. Dr. med. Karl F. Hilgers
Zeiten
nach Vereinbarung
Internistisches Zentrum (INZ)
Ulmenweg 18
91054 Erlangen
Room
D 0 723-1
Appointments only upon consultation
Hochschulambulanz
Montag bis Freitag
11.00 - 15.00 Uhr
Telefon: 09131 85-32566
Fax: 09131 85-33431
Hinweis
Diese Sprechstunde richtet sich an Patienten mit seltenen Formen der Hypertonie und Elektrolytstörungen.
Required documents
- Certificate of Insurance (health insurance card)
- Allocation
- Medication list
- Befundberichte von Ihrem Facharzt (falls vorhanden)