Prof. Dr. med. Karl F. Hilgers

Medizin 4

Transplantationszentrum

Prof. Dr. med. Karl F. Hilgers

Stellvertretender Direktor, Facharzt für Innere Medizin, Hypertensiologe (DHL)

Ulmenweg 18
91054 Erlangen

Building
Internistisches Zentrum (INZ)

Institutions
Medizin 4
Transplantationszentrum

karl.hilgers(at)uk-erlangen.de

Education, Training and Academic Positions

Publications

Rodionov RN, Jarzebska N, Burdin D, Todorov V, Martens-Lobenhoffer J, Hofmann A, Kolouschek A, Cordasic N, Jacobi J, Rubets E, Morawietz H, O'Sullivan JF, Markov AG, Bornstein SR, Hilgers K, Maas R, Pfluecke C, Chen Y, Bode-Böger SM, Hugo CPM, Hohenstein B, Weiss N: (2022) Overexpression of alanine-glyoxylate aminotransferase 2 protects from asymmetric dimethylarginine-induced endothelial dysfunction and aortic remodeling. Sci Rep. 2022;12(1):
Rodionova K, Ditting T, Hilgers KF, Peter L, Schmieder RE, Ott C, Schiffer M, Amann K, Veelken R: (2022) Empagliflozin Improves Impaired Sensitivity Of Afferent Neurons With Renal Axons Hypertension. 2022;79 Suppl 1():
Rodionova K, Ditting T, Linz P, Hilgers KF, Ott C, Schmieder RE, Schiffer M, Amann K, Veelken R: (2022) High Sodium Intake Effects On Afferent Renal Nerve Activity Hypertension. 2022;79 Suppl 1():
Saritas T, Reinartz S, Krueger T, Ketteler M, Liangos O, Labriola L, Stenvinkel P, Kopp C, Westenfeld R, Evenepoel P, Siepmann R, Wied S, Hilgers RD, Schurgers L, Floege J, VitaVasK Investigators: (2022) Vitamin K1 and progression of cardiovascular calcifications in hemodialysis patients: the VitaVasK randomized controlled trial Clin Kidney J. 2022;15(12): 2300-2311
Kovarik J, Morisawa N, Wild J, Marton A, Takase-Minegishi K, Minegishi S, Daub S, Sands JM, Klein JD, Bailey JL, Kovalik JP, Rauh M, Karbach S, Hilgers KF, Luft F, Nishiyama A, Nakano D, Kitada K, Titze J: (2021) Adaptive physiological water conservation explains hypertension and muscle catabolism in experimental chronic renal failure. Acta Physiol (Oxf). 2021;232(1):
Menendez-Castro C, Cordasic N, Fahlbusch FB, Ekici AB, Kirchner P, Daniel C, Amann K, Velkeen R, Wölfle J, Schiffer M, Hartner A, Hilgers KF: (2021) RNA sequencing reveals induction of specific renal inflammatory pathways in a rat model of malignant hypertension. J Mol Med. 2021;99(12): 1727-1740
Rodionova K, Hindermann M, Hilgers K, Ott C, Schmieder RE, Schiffer M, Amann K, Veelken R, Ditting T: (2021) AT II Receptor Blockade and Renal Denervation: Different Interventions with Comparable Renal Effects? Kidney Blood Press Res. 2021;46(3): 331-341
Rodionova K, Hilgers KF, Rafii-Tabrizi S, Doellner J, Cordasic N, Linz P, Karl AL, Ott C, Schmieder RE, Schiffer M, Amann K, Veelken R, Ditting T: (2021) Responsiveness of afferent renal nerve units in renovascular hypertension in rats. Pflugers Arch. 2021;473(10): 1617-1629
Raming R, Cordasic N, Kirchner P, Ekici AB, Fahlbusch FB, Woelfle J, Hilgers KF, Hartner A, Menendez-Castro C: (2021) Neonatal nephron loss during active nephrogenesis results in altered expression of renal developmental genes and markers of kidney injury. Physiol Genomics. 2021;53(12): 509-517
Rodionova K, Hilgers KF, Linz P, Schätzl J, Raschke G, Ott C, Schmieder RE, Schiffer M, Amann K, Veelken R, Ditting T: (2021) Neurogenic substance P-influences on action potential production in afferent neurons of the kidney? Pflugers Arch. 2021;473(4): 633-646
Rodionova K, Hilgers KF, Paulus EM, Tiegs G, Ott C, Schmieder R, Schiffer M, Amann K, Veelken R, Ditting T: (2020) Neurogenic tachykinin mechanisms in experimental nephritis of rats. Pflugers Arch. 2020;472(12): 1705-1717
Rodionova K, Veelken R, Hilgers KF, Paulus EM, Linz P, Fischer MJM, Schenker M, Reeh P, Tiegs G, Ott C, Schmieder R, Schiffer M, Amann K, Ditting T: (2020) Afferent renal innervation in anti-Thy1.1 nephritis in rats. Am J Physiol Renal Physiol. 2020;319(5): F822-F832
Menendez-Castro C, Cordasic N, Dambietz T, Veelken R, Amann K, Hartner A, Hilgers KF: (2020) Correlations Between Interleukin-11 Expression and Hypertensive Kidney Injury in a Rat Model of Renovascular Hypertension. Am J Hypertens. 2020;33(4): 331-340
Marek I, Hilgers KF, Rascher W, Woelfle J, Hartner A: (2020) A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney. Mol Cell Pediatr. 2020;7(1):
Rauen T, Wied S, Fitzner C, Eitner F, Sommerer C, Zeier M, Otte B, Panzer U, Budde K, Benck U, Mertens PR, Kuhlmann U, Witzke O, Gross O, Vielhauer V, Mann JFE, Hilgers RD, Floege J, STOP-IgAN Investigators , Floege J, Eitner F, Rauen T, Moeller MJ, Weihprecht H, Budde K, Peters H, Elitok S, Bieringer M, Schindler R, Frei U, Canaan-Kühl S, Erley C, Schlieps K, Kuhlmann U, Zandvoort F, Hohenstein B, Hugo C, Palm C, Hilgers K, Witzke O, Gross O, Panzer U, Haller H, Bertram A, Sommerer C, Zeier M, Wolf G, Busch M, Rath T, Ziefle S, Benzing T, Grundmann F, Mertens PR, Westphalen S, Benck U, Göttmann U, Vielhauer V, Fischereder M, Sarkar O, Stefanidou M, Mann JFE, Otte B, Pavenstädt H, Banas B, Boeger A, Heyne N, Artunc F, Reichel H, Mettang T, Wanner C, Metzger T, Wied S, Fitzner C, Hilgers RD: (2020) After ten years of follow-up, no difference between supportive care plus immunosuppression and supportive care alone in IgA nephropathy. Kidney Int. 2020;98(4): 1044-1052
Dienemann T, Schellenberg J, Heller K, Daniel C, Amann K, Hilgers KF, Schiffer M, Weidemann A: (2019) Association of donor hypertension and recipient renal function in living donor kidney transplantation: A single-center retrospective study. Clin Transplant. 2019;33(10):
Schmidt-Lauber C, Jacobi J, Polifka I, Hilgers KF, Wiesener MS: (2019) Suspected colonic cancer turns out to be disseminated tuberculosis in a kidney transplant recipient: A case report. Medicine (Baltimore). 2019;98(36):
Rother U, Amann K, Adler W, Nawroth N, Karampinis I, Keese M, Manap S, Regus S, Meyer A, Porubsky S, Hilgers K, Krämer BK, Lang W, Nowak K, Gerken ALH: (2019) Quantitative assessment of microperfusion by indocyanine green angiography in kidney transplantation resembles chronic morphological changes in kidney specimens. Microcirculation. 2019;26(3):
Mocker A, Hilgers KF, Cordasic N, Wachtveitl R, Menendez-Castro C, Woelfle J, Hartner A, Fahlbusch FB: (2019) Renal Chemerin Expression is Induced in Models of Hypertensive Nephropathy and Glomerulonephritis and Correlates with Markers of Inflammation and Fibrosis. Int J Mol Sci. 2019;20(24):
Rodionov R, Jarzebska N, Burdin D, Brilloff S, Todorov V, Martens-Lobenhoffer J, Hofmann A, Morawietz H, Hilgers KF, Cordasic N, Jacobi J, Maas R, Chen YJ, Bode-Boger S, Hohenstein B, Weiss N: (2019) Overexpression of Alanine-Glyoxylate Aminotransferase 2 in Mice Lowers Asymmetric Dimethylarginine and Improves Vasomotor Function Circulation. 2019;140 Suppl 1():
Wachter DL, Neureiter D, Câmpean V, Hilgers KF, Büttner-Herold M, Daniel C, Benz K, Amann K: (2018) In-situ analysis of mast cells and dendritic cells in coronary atherosclerosis in chronic kidney disease (CKD). Histol Histopathol. 2018;33(8): 871-886
Menendez-Castro C, Nitz D, Cordasic N, Jordan J, Bäuerle T, Fahlbusch FB, Rascher W, Hilgers KF, Hartner A: (2018) Neonatal nephron loss during active nephrogenesis - detrimental impact with long-term renal consequences. Sci Rep. 2018;8(1):
Schneider MP, Hilgers KF, Schmid M, Hübner S, Nadal J, Seitz D, Busch M, Haller H, Köttgen A, Kronenberg F, Baid-Agrawal S, Schlieper G, Schultheiss U, Sitter T, Sommerer C, Titze S, Meiselbach H, Wanner C, Eckardt KU, GCKD study Investigators: (2018) Blood pressure control in chronic kidney disease: A cross-sectional analysis from the German Chronic Kidney Disease (GCKD) study. PLoS ONE. 2018;13(8): e0202604
Schneider MP, Hilgers KF, Schmid M, Hübner S, Nadal J, Seitz D, Busch M, Haller H, Köttgen A, Kronenberg F, Baid-Agrawal S, Schlieper G, Schultheiss U, Sitter T, Sommerer C, Titze S, Meiselbach H, Wanner C, Eckardt KU, GCKD study Investigators: (2018) Correction: Blood pressure control in chronic kidney disease: A cross-sectional analysis from the German Chronic Kidney Disease (GCKD) study. PLoS ONE. 2018;13(9):
Benz K, Schlote J, Daniel C, Kopp C, Dahlmann A, Schröder A, Cordasic N, Klanke B, Hilgers K, Titze J, Amann K: (2018) Mild Salt-Sensitive Hypertension in Genetically Determined Low Nephron Number is Associated with Chloride but Not Sodium Retention. Kidney Blood Press Res. 2018;43(1): 1-11
Schellinger IN, Cordasic N, Panesar J, Buchholz B, Jacobi J, Hartner A, Klanke B, Jakubiczka-Smorag J, Burzlaff N, Heinze E, Warnecke C, Raaz U, Willam C, Tsao PS, Eckardt KU, Amann K, Hilgers KF: (2017) Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease. Kidney Int. 2017;91(3): 616-627
Schneider MP, Hilgers KF: (2017) Specific Aldosterone Synthase Inhibition: A Potential Improvement Over Mineralocorticoid Receptor Antagonism? Hypertension. 2017;69(1): 11-12
Rummo OO, Carmellini M, Rostaing L, Oberbauer R, Christiaans MH, Mousson C, Langer RM, Citterio F, Charpentier B, Brown M, Kazeem G, Lehner F, ADHERE study investigators , Heer M, Lim W, Mühlbacher F, Pratschke J, Bonvoisin C, Kuypers D, Dedochova J, Kuman M, Le Meur Y, Deteix P, Frimat L, Lang P, Lebranchu Y, Legendre C, Westeel PF, Schenker P, Hilgers KF, Witzke O, Hauser I, Kliem V, Zeier M, Kunzendorf U, Bartels M, Jonas S, Guba M, Wolters HH, Chan TM, Caputo F, Sparacino V, Nowicki M, Glyda M, Kim YS, Ha J, Kim CD, Han DJ, Kim YH, Perlin D, Sal'mayer A, Semchenko SB, Nesterenko I, Franco A, Grinyó J, Inza A, Ruiz JC, Chiang YJ, Lee PC, Suleymanlar G, Sevmis S, Kacar S: (2017) ADHERE: randomized controlled trial comparing renal function in de novo kidney transplant recipients receiving prolonged-release tacrolimus plus mycophenolate mofetil or sirolimus. Transpl Int. 2017;30(1): 83-95
Benz K, Varga I, Neureiter D, Campean V, Daniel C, Heim C, Reimann A, Weyand M, Hilgers KF, Amann K: (2017) Vascular inflammation and media calcification are already present in early stages of chronic kidney disease. Cardiovasc Pathol. 2017;27(): 57-67
Heiss RU, Fahlbusch F, Jacobi J, Daniel C, Ekici AB, Cordasic N, Amann K, Hartner A, Hilgers KF: (2017) Blunted transcriptional response to skeletal muscle ischemia in rats with chronic kidney disease: potential role for impaired ischemia-induced angiogenesis. Physiol Genomics. 2017;49(4): 230-237
Marek I, Canu M, Cordasic N, Rauh M, Volkert G, Fahlbusch FB, Rascher W, Hilgers KF, Hartner A, Menendez-Castro C: (2017) Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8. Biol Sex Differ. 2017;8(): 19
Rother U, Gerken ALH, Karampinis I, Klumpp M, Regus S, Meyer A, Apel H, Krämer BK, Hilgers K, Lang W, Nowak K: (2017) Dosing of indocyanine green for intraoperative laser fluorescence angiography in kidney transplantation. Microcirculation. 2017;24(8):
Schneider MP, Hilgers KF: (2017) [How to Retard Progression of Chronic Kidney Disease]. Dtsch Med Wochenschr. 2017;142(17): 1282-1289
Sekula P, Li Y, Stanescu HC, Wuttke M, Ekici AB, Bockenhauer D, Walz G, Powis SH, Kielstein JT, Brenchley P, GCKD Investigators , Eckardt KU, Kronenberg F, Kleta R, Köttgen A, Eckardt KU, Titze S, Prokosch HU, Bärthlein B, Reis A, Ekici AB, Gefeller O, Hilgers KF, Hübner S, Avendano S, Becker-Grosspitsch D, Hauck N, Seuchter SA, Hausknecht B, Rittmeier M, Weigel A, Beck A, Ganslandt T, Knispel S, Dressel T, Malzer M, Floege J, Eitner F, Schlieper G, Findeisen K, Arweiler E, Ernst S, Unger M, Lipski S, Schaeffner E, Baid-Agrawal S, Petzold K, Schindler R, Köttgen A, Schultheiss U, Meder S, Mitsch E, Reinhard U, Walz G, Haller H, Lorenzen J, Kielstein JT, Otto P, Sommerer C, Föllinger C, Zeier M, Wolf G, Busch M, Paul K, Dittrich L, Sitter T, Hilge R, Blank C, Wanner C, Krane V, Schmiedeke D, Toncar S, Cavitt D, Schönowsky K, Börner-Klein A, Kronenberg F, Raschenberger J, Kollerits B, Forer L, Schönherr S, Weißensteiner H, Oefner P, Gronwald W, Zacharias H, Schmid M: (2017) Genetic risk variants for membranous nephropathy: extension of and association with other chronic kidney disease aetiologies. Nephrol Dial Transplant. 2017;32(2): 325-332
Jacobi J, Beckmann S, Heller K, Hilgers KF, Apel H, Spriewald B, Eckardt KU, Amann KU: (2016) Deceased Donor Kidney Transplantation in the Eurotransplant Senior Program (ESP): A Single-Center Experience from 2008 to 2013. Ann Transplant. 2016;21(): 94-104
Marek I, Lichtneger T, Cordasic N, Hilgers KF, Volkert G, Fahlbusch F, Rascher W, Hartner A, Menendez-Castro C: (2016) Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover. PLoS ONE. 2016;11(3): e0150471
Busch M, Nadal J, Schmid M, Paul K, Titze S, Hübner S, Köttgen A, Schultheiss UT, Baid-Agrawal S, Lorenzen J, Schlieper G, Sommerer C, Krane V, Hilge R, Kielstein JT, Kronenberg F, Wanner C, Eckardt KU, Wolf G, GCKD study Investigators , Schlieper G, Findeisen K, Arweiler E, Ernst S, Unger M, Floege J, Schaeffner E, Baid-Agrawal S, Petzold K, Schindler R, Titze S, Hilgers K, Hübner S, Avendano S, Becker-Grosspitsch D, Eckardt KU, Köttgen A, Schultheiss U, Meder S, Mitsch E, Reinhard U, Walz G, Lorenzen J, Kielstein J, Otto P, Haller H, Sommerer C, Föllinger C, Löschner T, Zeier M, Busch M, Paul K, Dittrich L, Wolf G, Sitter T, Hilge R, Blank C, Fischereder M, Krane V, Schmiedeke D, Toncar S, Cavitt D, Schönowsky K, Franz S, Wanner C, Eckardt KU, Titze S, Hausknecht B, Rittmeier M, Weigel A, Prokosch HU, Bärthlein B, Haberländer K, Beck A, Ganslandt T, Knispel S, Dressel T, Gefeller O, Malzer M, Nadal J, Schmid M, Reis A, Ekici A, Kronenberg F, Kollerits B, Weißensteiner H, Forer L, Schönherr S, Oefner P, Gronwald W: (2016) Glycaemic control and antidiabetic therapy in patients with diabetes mellitus and chronic kidney disease - cross-sectional data from the German Chronic Kidney Disease (GCKD) cohort. BMC Nephrol. 2016;17(1): 59
Hartner A, Jagusch L, Cordasic N, Amann K, Veelken R, Jacobi J, Hilgers KF: (2016) Impaired Neovascularization and Reduced Capillary Supply in the Malignant vs. Non-malignant Course of Experimental Renovascular Hypertension. Front Physiol. 2016;7(): 370
Menendez-Castro C, Cordasic N, Neureiter D, Amann K, Marek I, Volkert G, Stintzing S, Jahn A, Rascher W, Hilgers KF, Hartner A: (2015) Under-expression of ?8 integrin aggravates experimental atherosclerosis. J Pathol. 2015;236(1): 5-16
Binger KJ, Gebhardt M, Heinig M, Rintisch C, Schroeder A, Neuhofer W, Hilgers K, Manzel A, Schwartz C, Kleinewietfeld M, Voelkl J, Schatz V, Linker RA, Lang F, Voehringer D, Wright MD, Hübner N, Dechend R, Jantsch J, Titze J, Müller DN: (2015) High salt reduces the activation of IL-4- and IL-13-stimulated macrophages. J Clin Invest. 2015;125(11): 4223-38
Rauen T, Eitner F, Fitzner C, Sommerer C, Zeier M, Otte B, Panzer U, Peters H, Benck U, Mertens PR, Kuhlmann U, Witzke O, Gross O, Vielhauer V, Mann JF, Hilgers RD, Floege J, STOP-IgAN Investigators , Floege J, Eitner F, Rauen T, Moeller MJ, Michaelis A, Weihprecht H, Baatz E, Söllner S, Peters H, Budde K, Markmann D, Elitok S, Bieringer M, Schindler R, Frei U, Canaan-Kühl S, Erley C, Schlieps K, Kuhlmann U, Zandvoort F, Bodemann ML, Hohenstein B, Hugo C, Palm C, Fleischer A, Hilgers K, Eckardt KU, Jank S, Witzke O, Kirchmeyer R, Gross O, Müller GA, Weber F, Birk HW, Feustel A, Jeßen S, Stahl RA, Panzer U, Kinzler E, Haller H, Bertram A, Bahlmann E, Zeier M, Sommerer C, Foellinger C, Wolf G, Busch M, Rüster C, Rath T, Ziefle S, Weik S, Benzing T, Bastek S, Kisner T, Mertens PR, Bosselmann HP, Piehler C, Westphalen S, Koepke S, Benck U, Göttmann U, Langhäuser B, Hoyer J, Maier T, Kortus-Goetze B, Vielhauer V, Fischereder M, Vilsmaier F, Sarkar O, Engelhardt S, Mann JF, Stefanidou M, Otte B, Pavenstädt H, George B, Banas B, Böger A, Emmer T, Weiner SM, Jochum E, Kiefer C, Heyne N, Artunc F, Georges G, Petermann A, Reichel H, Krumme B, Mettang T, Hirschberg M, Wanner C, Metzger T, Irmler-Mercier E: (2015) Intensive Supportive Care plus Immunosuppression in IgA Nephropathy. N Engl J Med. 2015;373(23): 2225-36
Arend N, Hilgers KF, Campean V, Karpe B, Cordasic N, Klanke B, Amann K: (2014) Darbepoetin alpha reduces oxidative stress and chronic inflammation in atherosclerotic lesions of apo e deficient mice in experimental renal failure. PLoS ONE. 2014;9(2): e88601
Volkert G, Jahn A, Dinkel C, Fahlbusch F, Zürn C, Hilgers KF, Rascher W, Hartner A, Marek I: (2014) Contribution of the ?8 integrin chain to the expression of extracellular matrix components. Cell Commun Adhes. 2014;21(2): 89-98
Schneider MP, Hilgers KF: (2014) What should be the goal blood pressure in nondiabetic chronic kidney disease? Curr Opin Nephrol Hypertens. 2014;23(2): 180-5
Jacobi J, Maas R, Arend M, Cordasic N, Hilgers KF: (2014) Effect of lowering asymmetric dimethylarginine (ADMA) on vascular pathology in atherosclerotic ApoE-deficient mice with reduced renal mass. Int J Mol Sci. 2014;15(4): 5522-35
Menendez-Castro C, Toka O, Fahlbusch F, Cordasic N, Wachtveitl R, Hilgers KF, Rascher W, Hartner A: (2014) Impaired myocardial performance in a normotensive rat model of intrauterine growth restriction. Pediatr Res. 2014;75(6): 697-706
Jacobi J, Rebhan D, Heller K, Velden J, Hilgers KF, Wullich B, Eckardt KU, Amann KU: (2014) Donor acute kidney injury and short-term graft outcome in renal transplantation. Clin Transplant. 2014;28(10): 1131-41
Marek I, Volkert G, Hilgers KF, Bieritz B, Rascher W, Reinhardt DP, Hartner A: (2014) Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus and interact to convey adhesion of mesangial cells. Cell Adh Migr. 2014;8(4): 389-95
Hartner Andrea, Cordasic Nada, Klanke Bernd, Menendez-Castro Carlos, Veelken Roland, Schmieder RolandE, Hilgers KarlF: (2014) Renal protection by low dose irbesartan in diabetic nephropathy is paralleled by a reduction of inflammation, not of endoplasmic reticulum stress Biochim Biophys Acta Mol Basis Dis. 2014;1842(4): 558-565
Freisinger W, Karl A, Ditting T, Heinlein S, Ott C, Hilgers KF, Schmieder RE, Linz P, Schatz J, Veelken R: (2013) Reduced Firing Activity of Afferent Renal Innervation in the 2kidney/1clip Model of Hypertension Hypertension. 2013;62 S(3): -
Paul K, Kretzschmar D, Yilmaz A, Bärthlein B, Titze S, Wolf G, Busch M, GCKD-Study Investigators , Eitner F, Schlieper G, Findeisen K, Arweiler E, Ernst S, Unger M, Floege J, Schaeffner E, Baid-Agrawal S, Petzold K, Schindler R, Hilgers KF, Hübner S, Avendano S, Becker-Grosspietsch D, Köttgen A, Schultheiss U, Meder S, Mitsch E, Walz G, Lorenzen J, Kielstein JT, Otto P, Haller H, Sommerer C, Föllinger C, Löschner T, Zeier M, Busch M, Paul K, Dittrich L, Wolf G, Sitter T, Hilge R, Blank C, Krane V, Schmiedeke D, Toncar S, Cavitt D, Wanner C, Franz S, Eckardt KU, Titze S, Hauck N, Seuchter SA, Hausknecht B, Rittmeier M, Weigel A, Prokosch HU, Bärthlein B, Haberländer K, Beck A, Ganslandt T, Stefan S, Knispel S, Dressel T, Gefeller O, Schmid M, Malzer M, Reis A, Ekici AB, Kronenberg F, Kollerits B, Weißensteiner H, Forer L, Schönherr S, Oefner P, Gronwald W: (2013) Circulating dendritic cell precursors in chronic kidney disease: a cross-sectional study. BMC Nephrol. 2013;14(): 274
Menendez-Castro C, Hilgers KF, Amann K, Daniel C, Cordasic N, Wachtveitl R, Fahlbusch F, Plank C, Dötsch J, Rascher W, Hartner A: (2013) Intrauterine growth restriction leads to a dysregulation of Wilms' tumour supressor gene 1 (WT1) and to early podocyte alterations. Nephrol Dial Transplant. 2013;28(6): 1407-17
Hilgers KF: (2013) Hypertension: Resistant hypertension matters in chronic kidney disease. Nat Rev Nephrol. 2013;9(8): 441-2
Jacobi J, Prignitz A, Buttner M, Korn K, Weidemann A, Hilgers KF, Heller K, Velden J, Knöll A, Wullich B, May C, Eckardt KU, Amann KU: (2013) BK viremia and polyomavirus nephropathy in 352 kidney transplants; risk factors and potential role of mTOR inhibition. BMC Nephrol. 2013;14(): 207
Schlote J, Schröder A, Dahlmann A, Karpe B, Cordasic N, Daniel C, Hilgers KF, Titze J, Amann K, Benz K: (2013) Cardiovascular and Renal Effects of High Salt Diet in GDNF+/- Mice with Low Nephron Number. Kidney Blood Press Res. 2013;37(4-5): 379-91
Menendez-Castro C, Cordasic N, Schmid M, Fahlbusch F, Rascher W, Amann K, Hilgers KF, Hartner A: (2012) Intrauterine growth restriction promotes vascular remodelling following carotid artery ligation in rats. Clin Sci (Lond). 2012;123(7): 437-44
Mann J, Hilgers K, Veelken R, Luft F: (2012) An experimental procedure paid for by the general public. Dtsch Arztebl Int. 2012;109(17): 311-2; author reply 313-4
Hartner A, Menendez-Castro C, Cordasic N, Marek I, Volkert G, Klanke B, Rascher W, Hilgers KF: (2012) Tubulointerstitial de novo expression of the ?8 integrin chain in a rodent model of renal fibrosis - a potential target for anti-fibrotic therapy? PLoS ONE. 2012;7(11): e48362
Eckardt KU, Bärthlein B, Baid-Agrawal S, Beck A, Busch M, Eitner F, Ekici AB, Floege J, Gefeller O, Haller H, Hilge R, Hilgers KF, Kielstein JT, Krane V, Köttgen A, Kronenberg F, Oefner P, Prokosch HU, Reis A, Schmid M, Schaeffner E, Schultheiss UT, Seuchter SA, Sitter T, Sommerer C, Walz G, Wanner C, Wolf G, Zeier M, Titze S: (2012) The German Chronic Kidney Disease (GCKD) study: design and methods. Nephrol Dial Transplant. 2012;27(4): 1454-60
Knier B, Bueschges-Seraphin B, Hilgers KF, Amann KU, Uder M, Eckardt KU, Jacobi J: (2012) From red to white urine: a patient's nightmare with a rather benign outcome. BMC Nephrol. 2012;13(): 7
Hinkes B, Hilgers KF, Bolz HJ, Goppelt-Struebe M, Amann K, Nagl S, Bergmann C, Rascher W, Eckardt KU, Jacobi J: (2012) A complex microdeletion 17q12 phenotype in a patient with recurrent de novo membranous nephropathy. BMC Nephrol. 2012;13(): 27
Benz K, Câmpean V, Cordasic N, Karpe B, Neuhuber W, Mall G, Hartner A, Hilgers KF, Amann K: (2011) Early glomerular alterations in genetically determined low nephron number. Am J Physiol Renal Physiol. 2011;300(2): F521-30
Amann K, Odoni G, Benz K, Câmpean V, Jacobi J, Hilgers KF, Hartner A, Veelken R, Orth SR: (2011) Sympathetic blockade prevents the decrease in cardiac VEGF expression and capillary supply in experimental renal failure. Am J Physiol Renal Physiol. 2011;300(1): F105-12
Tyralla K, Adamczak M, Benz K, Câmpean V, Gross ML, Hilgers KF, Ritz E, Amann K: (2011) High-dose enalapril treatment reverses myocardial fibrosis in experimental uremic cardiomyopathy. PLoS ONE. 2011;6(1): e15287
Ott C, Schneider MP, Delles C, Schlaich MP, Hilgers KF, Schmieder RE: (2011) Association of (pro)renin receptor gene polymorphism with blood pressure in Caucasian men. Pharmacogenet Genomics. 2011;21(6): 347-9
Menendez-Castro C, Fahlbusch F, Cordasic N, Amann K, Münzel K, Plank C, Wachtveitl R, Rascher W, Hilgers KF, Hartner A: (2011) Early and late postnatal myocardial and vascular changes in a protein restriction rat model of intrauterine growth restriction. PLoS ONE. 2011;6(5): e20369
Knier B, Cordasic N, Klanke B, Heusinger-Ribeiro J, Daniel C, Veelken R, Hartner A, Hilgers KF: (2011) Effect of the plasminogen-plasmin system on hypertensive renal and cardiac damage. J Hypertens. 2011;29(8): 1602-12
Jacobi J, Schnellhardt S, Kulschewski A, Amann KU, Kuefner MA, Eckardt KU, Hilgers KF: (2010) An unusual case of hyponatraemia. Nephrol Dial Transplant. 2010;25(3): 998-1001
Jacobi J, Maas R, Cardounel AJ, Arend M, Pope AJ, Cordasic N, Heusinger-Ribeiro J, Atzler D, Strobel J, Schwedhelm E, Böger RH, Hilgers KF: (2010) Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine. Am J Pathol. 2010;176(5): 2559-70
Jacobi J, Schnellhardt S, Opgenoorth M, Amann KU, Küttner A, Schmid A, Eckardt KU, Hilgers KF: (2010) Severe metabolic alkalosis and recurrent acute on chronic kidney injury in a patient with Crohn's disease. BMC Nephrol. 2010;11(): 6
Jacobi J, Hilgers KF, Lang W, Eckardt KU, Uder M: (2010) Images in vascular medicine: Renal arteriovenous fistula. Vasc Med. 2010;15(5): 433-4
Geissler B, Plank C, Hartner A, Amann K, Struwe FG, Hilgers KF, Rascher W, Dötsch J: (2010) Effects of adrenomedullin on the glomerular adrenomedullin system in a rat model of anti-thy1 glomerulonephritis. Nephron Exp Nephrol. 2010;115(3): e80-8
Hartner A, Cordasic N, Menendez-Castro C, Volkert G, Yabu JM, Kupraszewicz-Hutzler M, Rascher W, Hilgers KF: (2010) Lack of {alpha}8-integrin aggravates podocyte injury in experimental diabetic nephropathy. Am J Physiol Renal Physiol. 2010;299(5): F1151-7
Marek I, Volkert G, Jahn A, Fahlbusch F, Zürn C, Ozcan Z, Goppelt-Struebe M, Hilgers KF, Rascher W, Hartner A: (2010) Lack of ?8 integrin leads to morphological changes in renal mesangial cells, but not in vascular smooth muscle cells. BMC Cell Biol. 2010;11(): 102
Hartner A, Cordasic N, Rascher W, Hilgers KF: (2009) Deletion of the alpha8 integrin gene does not protect mice from myocardial fibrosis in DOCA hypertension. Am J Hypertens. 2009;22(1): 92-9
Ritt M, Ott C, Raff U, Schneider MP, Schuster I, Hilgers KF, Schlaich MP, Schmieder RE: (2009) Renal vascular endothelial function in hypertensive patients with type 2 diabetes mellitus. Am J Kidney Dis. 2009;53(2): 281-9
Amann K, Haas CS, Zeiler GA, Benz K, Bader BL, Hartner A, Hilgers KF: (2009) Lack of nidogen-2 increases blood pressure, glomerular and tubulointerstitial damage in DOCA-salt hypertension. Eur J Clin Invest. 2009;39(2): 116-25
Hartner A, Klanke B, Cordasic N, Amann K, Schmieder RE, Veelken R, Hilgers KF: (2009) Statin treatment reduces glomerular inflammation and podocyte damage in rat deoxycorticosterone-acetate-salt hypertension. J Hypertens. 2009;27(2): 376-85
Machnik A, Neuhofer W, Jantsch J, Dahlmann A, Tammela T, Machura K, Park JK, Beck FX, Muller DN, Derer W, Goss J, Ziomber A, Dietsch P, Wagner H, van Rooijen N, Kurtz A, Hilgers KF, Alitalo K, Eckardt KU, Luft FC, Kerjaschki D, Titze J: (2009) Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med. 2009;15(5): 545-52
Hilgers KF: (2009) [In Process Citation] Urologe A. 2009;48(8): 925-33; quiz 934-5
Machura K, Steppan D, Neubauer B, Alenina N, Coffman TM, Facemire CM, Hilgers KF, Eckardt KU, Wagner C, Kurtz A: (2009) Developmental renin expression in mice with a defective renin-angiotensin system. Am J Physiol Renal Physiol. 2009;297(5): F1371-80
Stumpf C, Hilgers KF: (2009) C-reactive protein: more than just a marker of inflammation? J Hypertens. 2009;27(9): 1748-9
Ritz E, Krum H, Schlaich M, Whitbourn R, Sobotka PA, Sadowski J, Bartus K, Kapelak B, Walton A, Sievert H, Thambar S, Abraham WT, Esler M, Wang Y, Tsun Z, Machnik A, Neuhofer W, Jantsch J, Dahlmann A, Tammela T, Machura K, Park JK, Beck FX, Muller DN, Derer W, Goss J, Ziomber A, Dietsch P, Wagner H, van Rooijen N, Kurtz A, Hilgers KF, Alitalo K, Eckardt KU, Luft FC, Kerjaschki D, Titze J: (2009) New approaches to pathogenesis and management of hypertension. Clin J Am Soc Nephrol. 2009;4(12): 1886-91
Muller DN, Klanke B, Feldt S, Cordasic N, Hartner A, Schmieder RE, Luft FC, Hilgers KF: (2008) (Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in goldblatt rats. Hypertension. 2008;51(3): 676-81
Zeltner R, Hilgers KF, Schmieder RE, Porst M, Schulze BD, Hartner A: (2008) A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease. Nephron Clin Pract. 2008;108(3): c169-75
Mann J, Hilgers KF, Veelken R, Lenhardt C, Schiffrin EL: (2008) [Chronic kidney disease and the cardiovascular system.] Internist (Berl). 2008;49(4): 413-21
Handtrack C, Knorr H, Amann KU, Schoerner C, Hilgers KF, Geißdörfer W: (2008) Acute syphilitic chorioretinitis after a missed primary diagnosis: a case report. J Med Case Reports. 2008;2(1): 33
Veelken R, Vogel EM, Hilgers K, Amann K, Hartner A, Sass G, Neuhuber W, Tiegs G: (2008) Autonomic renal denervation ameliorates experimental glomerulonephritis. J Am Soc Nephrol. 2008;19(7): 1371-8
Klanke B, Cordasic N, Hartner A, Schmieder RE, Veelken R, Hilgers KF: (2008) Blood pressure versus direct mineralocorticoid effects on kidney inflammation and fibrosis in DOCA-salt hypertension. Nephrol Dial Transplant. 2008;23(11): 3456-63
Westhoff JH, Hilgers KF, Steinbach MP, Hartner A, Klanke B, Amann K, Melk A: (2008) Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a. Hypertension. 2008;52(1): 123-9
Ditting T, Veelken R, Hilgers KF: (2008) Transient receptor potential vanilloid type 1 receptors in hypertensive renal damage: a promising therapeutic target? Hypertension. 2008;52(2): 213-4
Hilgers KF, Mann JF: (2008) The choice of antihypertensive therapy in patients with the metabolic syndrome--time to change recommendations? Nephrol Dial Transplant. 2008;23(11): 3389-91
Mann J, Hilgers KF, Veelken R, Kunz R: (2008) [The kidneys and the heart] Dtsch Med Wochenschr. 2008;133(37): 1839-43
Ziomber A, Machnik A, Dahlmann A, Dietsch P, Beck FX, Wagner H, Hilgers KF, Luft FC, Eckardt KU, Titze J: (2008) Sodium-, potassium-, chloride-, and bicarbonate-related effects on blood pressure and electrolyte homeostasis in deoxycorticosterone acetate-treated rats. Am J Physiol Renal Physiol. 2008;295(6): F1752-63
Bertog M, Cuffe JE, Pradervand S, Hummler E, Hartner A, Porst M, Hilgers KF, Rossier BC, Korbmacher C: (2008) Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome. J Physiol. 2008;586(Pt 2): 459-75
Kirchhoff F, Krebs C, Abdulhag UN, Meyer-Schwesinger C, Maas R, Helmchen U, Hilgers KF, Wolf G, Stahl RA, Wenzel U: (2008) Rapid development of severe end-organ damage in C57BL/6 mice by combining DOCA salt and angiotensin II. Kidney Int. 2008;73(5): 643-50
Hartner A, Marek I, Cordasic N, Haas C, Schöcklmann H, Hulsmann-Volkert G, Plasa I, Rascher W, Hilgers KF, Amann K: (2008) Glomerular regeneration is delayed in nephritic alpha 8-integrin-deficient mice: contribution of alpha 8-integrin to the regulation of mesangial cell apoptosis. Am J Nephrol. 2008;28(1): 168-78
Jacobi J, Maas R, Cordasic N, Koch K, Schmieder RE, Böger RH, Hilgers KF: (2008) Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice. Am J Physiol Heart Circ Physiol. 2008;294(2): H1058-66
Hartner A, Cordasic N, Klanke B, Wittmann M, Veelken R, Hilgers KF: (2007) Renal injury in streptozotocin-diabetic Ren2-transgenic rats is mainly dependent on hypertension, not on diabetes. Am J Physiol Renal Physiol. 2007;292(2): F820-7
Schafflhuber M, Volpi N, Dahlmann A, Hilgers KF, Maccari F, Dietsch P, Wagner H, Luft FC, Eckardt KU, Titze J: (2007) Mobilization of osmotically inactive Na+ by growth and by dietary salt restriction in rats. Am J Physiol Renal Physiol. 2007;292(5): F1490-500

Consultations

Elektrolytstörungen

Special consultation hour

PD Dr. med. Christoph Kopp
Prof. Dr. med. Karl F. Hilgers

Zeiten
nach Vereinbarung

Internistisches Zentrum (INZ)
Ulmenweg 18
91054 Erlangen

Room
D 0 723-1

Contact for appointments
Appointments only upon consultation

Hochschulambulanz
Montag bis Freitag
11.00 - 15.00 Uhr
Telefon: 09131 85-32566
Fax: 09131 85-33431

Hinweis

Diese Sprechstunde richtet sich an Patienten mit seltenen Formen der Hypertonie und Elektrolytstörungen.

Required documents

Certificate of Insurance (health insurance card)
Allocation
Medication list
Befundberichte von Ihrem Facharzt (falls vorhanden)

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Prof. Dr. med. Karl F. Hilgers