Dr. Gunnar Schley - Medizin 4 | Universitätsklinikum Erlangen

Publikationsliste Dr. Gunnar Schley

Schley G, Willam C: (2021) ["Intravascular space contracted-tissue space expanded": interstitial edema and fluid management in intensive care medicine]. Med Klin Intensivmed Notfmed. 2021;116(8): 665-671
Willam C, Schley G: (2021) [Intravenous fluid therapy and acute kidney injury - What's new?] Dtsch Med Wochenschr. 2021;146(15): 977-981
Schley G, Grampp S, Goppelt-Struebe M: (2020) Inhibition of oxygen-sensing prolyl hydroxylases increases lipid accumulation in human primary tubular epithelial cells without inducing ER stress. Cell Tissue Res. 2020;381(1): 125-140
Schley G, Rosen S, Heyman SN: (2020) Soluble Urokinase Receptor and Acute Kidney Injury. N Engl J Med. 2020;382(22):
Mayer M, Fey K, Heinze E, Wick CR, Abboud MI, Yeh TL, Tumber A, Orth N, Schley G, Buchholz B, Clark T, Schofield CJ, Willam C, Burzlaff N: (2019) A Fluorescent Benzo[g]isoquinoline-Based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging. ChemMedChem. 2019;14(1): 94-99
Schley G, Klanke B, Kalucka J, Schatz V, Daniel C, Mayer M, Goppelt-Struebe M, Herrmann M, Thorsteinsdottir M, Palsson R, Beneke A, Katschinski DM, Burzlaff N, Eckardt KU, Weidemann A, Jantsch J, Willam C: (2019) Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritis. Kidney Int. 2019;96(2): 378-396
Daniel C, Leppkes M, Munoz LE, Schley G, Schett G, Herrmann M: (2019) Extracellular DNA traps in inflammation, injury and healing. Nat Rev Nephrol. 2019;15(9): 559-575
Schley G, Jordan J, Ellmann S, Rosen S, Eckardt KU, Uder M, Willam C, Bäuerle T: (2019) Correction: Multiparametric magnetic resonance imaging of experimental chronic kidney disease: A quantitative correlation study with histology. PLoS ONE. 2019;14(6):
Schreiber R, Buchholz B, Kraus A, Schley G, Scholz J, Ousingsawat J, Kunzelmann K: (2019) Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A. J Am Soc Nephrol. 2019;30(2): 228-242
Schley G, Jordan J, Ellmann S, Rosen S, Eckardt KU, Uder M, Willam C, Bäuerle T: (2018) Multiparametric magnetic resonance imaging of experimental chronic kidney disease: A quantitative correlation study with histology. PLoS ONE. 2018;13(7):
Kraus A, Peters DJM, Klanke B, Weidemann A, Willam C, Schley G, Kunzelmann K, Eckardt KU, Buchholz B: (2018) HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease. Kidney Int. 2018;94(5): 887-899
Buchholz B, Schley G, Eckardt KU: (2016) The impact of hypoxia on nephrogenesis. Curr Opin Nephrol Hypertens. 2016;25(3): 180-6
Kraus A, Grampp S, Goppelt-Struebe M, Schreiber R, Kunzelmann K, Peters DJ, Leipziger J, Schley G, Schödel J, Eckardt KU, Buchholz B: (2016) P2Y2R is a direct target of HIF-1? and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells. Purinergic Signal. 2016;12(4): 687-695
Schatz V, Strüssmann Y, Mahnke A, Schley G, Waldner M, Ritter U, Wild J, Willam C, Dehne N, Brüne B, McNiff JM, Colegio OR, Bogdan C, Jantsch J: (2016) Myeloid Cell-Derived HIF-1? Promotes Control of Leishmania major. J Immunol. 2016;197(10): 4034-4041
Kraus A, Schley G, Kunzelmann K, Schreiber R, Peters DJ, Stadler R, Eckardt KU, Buchholz B: (2016) Glucose promotes secretion-dependent renal cyst growth. J Mol Med. 2016;94(1): 107-17
Vogler M, Zieseniss A, Hesse AR, Levent E, Tiburcy M, Heinze E, Burzlaff N, Schley G, Eckardt KU, Willam C, Katschinski DM: (2015) Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult. Pflugers Arch. 2015;467(10): 2141-9
Zacharias HU, Hochrein J, Vogl FC, Schley G, Mayer F, Jeleazcov C, Eckardt KU, Willam C, Oefner PJ, Gronwald W: (2015) Identification of Plasma Metabolites Prognostic of Acute Kidney Injury after Cardiac Surgery with Cardiopulmonary Bypass. J Proteome Res. 2015;14(7): 2897-905
Schulz K, Hagos Y, Burckhardt G, Schley G, Burzlaff N, Willam C, Burckhardt BC: (2015) The Isoquinolone Derived Prolyl Hydroxylase Inhibitor ICA Is a Potent Substrate of the Organic Anion Transporters 1 and 3. Nephron. 2015;131(4): 285-9
Kalucka J, Schley G, Georgescu A, Klanke B, Rössler S, Baumgartl J, Velden J, Amann K, Willam C, Johnson RS, Eckardt KU, Weidemann A: (2015) Kidney injury is independent of endothelial HIF-1?. J Mol Med. 2015;93(8): 891-904
Schley G, Köberle C, Manuilova E, Rutz S, Forster C, Weyand M, Formentini I, Kientsch-Engel R, Eckardt KU, Willam C: (2015) Comparison of Plasma and Urine Biomarker Performance in Acute Kidney Injury. PLoS ONE. 2015;10(12): e0145042
Siegert I, Schödel J, Nairz M, Schatz V, Dettmer K, Dick C, Kalucka J, Franke K, Ehrenschwender M, Schley G, Beneke A, Sutter J, Moll M, Hellerbrand C, Wielockx B, Katschinski DM, Lang R, Galy B, Hentze MW, Koivunen P, Oefner PJ, Bogdan C, Weiss G, Willam C, Jantsch J: (2015) Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1? upon LPS Activation in the Presence of Ample Oxygen. Cell Rep. 2015;13(10): 2048-55
Vogler M, Zieseniss A, Hesse AR, Levent E, Tiburcy M, Heinze E, Burzlaff N, Schley G, Eckardt KU, Willam C, Katschinski D: (2015) Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult Acta Physiol (Oxf). 2015;213 699(): 79-80
Schley G, Scholz H, Kraus A, Hackenbeck T, Klanke B, Willam C, Wiesener MS, Heinze E, Burzlaff N, Eckardt KU, Buchholz B: (2015) Hypoxia inhibits nephrogenesis through paracrine Vegfa despite the ability to enhance tubulogenesis. Kidney Int. 2015;88(6): 1283-1292
Tian W, Wang Y, Xu Y, Guo X, Wang B, Sun L, Liu L, Cui F, Zhuang Q, Bao X, Schley G, Chung TL, Laslett AL, Willam C, Qin B, Maxwell PH, Esteban MA: (2014) The hypoxia-inducible factor renders cancer cells more sensitive to vitamin C-induced toxicity. J Biol Chem. 2014;289(6): 3339-51
Buchholz B, Schley G, Faria D, Kroening S, Willam C, Schreiber R, Klanke B, Burzlaff N, Jantsch J, Kunzelmann K, Eckardt KU: (2014) Hypoxia-Inducible Factor-1? Causes Renal Cyst Expansion through Calcium-Activated Chloride Secretion. J Am Soc Nephrol. 2014;25(3): 465-74
Buchholz B, Faria D, Schley G, Schreiber R, Eckardt KU, Kunzelmann K: (2014) Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells. Kidney Int. 2014;85(5): 1058-67
Schietke RE, Hackenbeck T, Tran M, Günther R, Klanke B, Warnecke CL, Knaup KX, Shukla D, Rosenberger C, Koesters R, Bachmann S, Betz P, Schley G, Schödel J, Willam C, Winkler T, Amann K, Eckardt KU, Maxwell P, Wiesener MS: (2012) Renal Tubular HIF-2? Expression Requires VHL Inactivation and Causes Fibrosis and Cysts. PLoS ONE. 2012;7(1): e31034
Schley G, Klanke B, Schödel J, Kröning S, Türkoglu G, Beyer A, Hagos Y, Amann K, Burckhardt BC, Burzlaff N, Eckardt KU, Willam C: (2012) Selective stabilization of HIF-1? in renal tubular cells by 2-oxoglutarate analogues. Am J Pathol. 2012;181(5): 1595-606
Wang Z, Schley G, Türkoglu G, Burzlaff N, Amann KU, Willam C, Eckardt KU, Bernhardt WM: (2012) The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment. Nephrol Dial Transplant. 2012;27(3): 929-36
Buchholz B, Teschemacher B, Schley G, Schillers H, Eckardt KU: (2011) Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP- and ATP-mediated fluid secretion. J Mol Med. 2011;89(3): 251-61
Buchholz B, Klanke B, Schley G, Bollag G, Tsai J, Kroening S, Yoshihara D, Wallace DP, Kraenzlin B, Gretz N, Hirth P, Eckardt KU, Bernhardt WM: (2011) The Raf kinase inhibitor PLX5568 slows cyst proliferation in rat polycystic kidney disease but promotes renal and hepatic fibrosis. Nephrol Dial Transplant. 2011;26(11): 3458-65
Schley G, Klanke B, Schödel J, Forstreuter F, Shukla D, Kurtz A, Amann K, Wiesener MS, Rosen S, Eckardt KU, Maxwell PH, Willam C: (2011) Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury. J Am Soc Nephrol. 2011;22(11): 2004-15
Schödel J, Bohr D, Klanke B, Schley G, Schlotzer-Schrehardt U, Warnecke C, Kurtz A, Amann K, Eckardt KU, Willam C: (2010) Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells. Kidney Int. 2010;78(9): 857-67
Volke M, Gale DP, Maegdefrau U, Schley G, Klanke B, Bosserhoff AK, Maxwell PH, Eckardt KU, Warnecke C: (2009) Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors. PLoS ONE. 2009;4(11): e7875